3-Phenylcoumarins as inhibitors of HIV-1 replication

…, R Sancho, LM Bedoya, JL López-Pérez, E del Olmo…

Index: Olmedo, Dionisio; Sancho, Rocio; Bedoya, Luis M.; Lopez-Perez, Jose L.; Del Olmo, Esther; Munoz, Eduardo; Alcami, Jose; Gupta, Mahabir P.; Feliciano, Arturo San Molecules, 2012 , vol. 17, # 8 p. 9245 - 9257

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Citation Number: 28

Abstract

Abstract: We have synthesized fourteen 3-phenylcoumarin derivatives and evaluated their anti-HIV activity. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase gene as reporter. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Six compounds displayed NF-κ B inhibition, four resulted Tat antagonists and three of them showed both ...