Journal of Heterocyclic Chemistry

… the Synthesis of Ketanserin () and its Hydrochloride Salt () via 3??(2??Chloroethyl)??2, 4??(1H, 3H)??quinazolinedione () or Dihydro??5H??oxazole (2, 3??b) quinazolin??5??one …

H Fakhraian, M Heydary

Index: Fakhraian, Hossein; Heydary, Mehdi Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 151 - 156

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Abstract

Abstract The synthesis of ketanserin (5) and its hydrochloride salt (5. HCl) using respectively equimolar amounts of 3-(2-chloroethyl)-2, 4-(1H, 3H)-quinazolinedione (2) with 4- (parafluorobenzoyl) piperidine (3) and dihydro-5H-oxazole (2, 3-b) quinazolin-5-one (1) with hydrochloride salt of 4-(parafluorobenzoyl) piperidine (3. HCl) is reinvestigated. The one-pot reaction of ethyl-2-aminobenzoate with ethyl chloroformate and ethanol amine has ...

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