An efficient acylation/base-catalyzed cyclization of thioureas affords N, N′-disubstituted thiobarbituric acids

…, RF Lowe, JR McCarthy, LO Weigel, JP Whitten

Index: Heath, Perry C.; Huang, Charles Q.; Lowe, Richard F.; McCarthy, James R.; Weigel, Leland O.; Whitten, Jeffery P. Tetrahedron Letters, 2001 , vol. 42, # 9 p. 1607 - 1610

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Citation Number: 7

Abstract

Certain substituted 2-thiobarbituric acids have long been used as intravenous anesthetics 1 and as intermediates in the preparation of dyes. 10a More recently there has been interest in 2-thiobarbituric acids as anticonvulsants, 2., and immunotropic and anti-inflammatory compounds, 3 antineoplastic agents, 4 and as platforms in the synthesis of other biologically active compounds. 5., , and While deceptively simple in structure, 1,3-disubstituted-2- ...