Copper-catalyzed one-pot synthesis of 2-thioxo-2, 3-dihydroquinazolin-4 (1H)-ones from ortho-bromobenzamides and isothiocyanates

F Wang, P Zhao, C Xi

Index: Wang, Fei; Zhao, Peng; Xi, Chanjuan Tetrahedron Letters, 2011 , vol. 52, # 2 p. 231 - 235

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Citation Number: 21

Abstract

Copper-catalyzed tandem reaction of ortho-bromobenzamides and isothiocyanates is described, which provides an efficient and practical route for the synthesis of 2-thioxo-2, 3- dihydroquinazolin-4 (1H)-ones. The optimal condition involved the following parameters: CuI as precatalyst, Cs2CO3 as base, N, N′-dimethylethane-1, 2-diamine as ligand, and toluene as solvent, with reaction temperature at 120° C.