A modified, economical and efficient synthesis of variably substituted pyrazolo [4, 3??d] pyrimidin??7??ones

KM Khan, GM Maharvi, MI Choudhary…

Index: Khan, Khalid Mohammed; Maharvi, Ghulam Murtaza; Choudhary, Muhammad Iqbal; Atta-Ur-Rahman; Perveen, Shahnaz Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 6 p. 1085 - 1093

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Citation Number: 6

Abstract

Abstract 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid (3) was exclusively brominated at the 4-position by bromine in the dark. Brominated product 8 was then converted into 1- methyl-3-propyl-1H-pyrazole-5-car-boxamide 9 by successive treatment with thionyl chloride and ammonium hydroxide. Carboxamide 9 was treated with various aroyl amides under microwave (MW) irradiation to afford 4-aroylamino-1-methyl-3-propyl-1H-pyrazole-5- ...