Catalytic Asymmetric Dihydroxylation of Enamides and Application to the Total Synthesis of (+)??Tanikolide

B Gourdet, HW Lam

Index: Gourdet, Benoit; Lam, Hon Wai Angewandte Chemie - International Edition, 2010 , vol. 49, # 46 p. 8733 - 8737

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Citation Number: 29

Abstract

Asymmetric transformations of 1, 1-disubstituted alkenes provide important building blocks for chemical synthesis, but are often plagued with low stereoselectivities because it can be difficult for a chiral reagent or catalyst to discriminate between the enantiotopic faces of these substrates.[1] Among the available methods, asymmetric dihydroxylation (AD) stands out as one of the more successful, and can provide high enantioselectivities in certain ...