Bioorganic & medicinal chemistry letters

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

A Gupte, JK Buolamwini

Index: Gupte, Amol; Buolamwini, John K. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 917 - 921

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Citation Number: 25

Abstract

Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotective and neuroprotective agents. Although quite a few potent inhibitors of the equilibrative nucleoside transporters are known, largely missing are the concentrative nucleoside transporter inhibitors. Phloridzin (3, Ki= 16.00 μM) is a known moderate inhibitor of the concentrative nucleoside transporters. We have synthesized and evaluated analogs ...