Uncatalysed preparation of α-amino phosphonates under solvent free conditions
M Zahouily, A Elmakssoudi, A Mezdar…
Index: Zahouily, Mohamed; Elmakssoudi, Abdelhakim; Mezdar, Abdessamad; Rayadh, Ahmed; Sebti, Said Journal of Chemical Research, 2005 , # 5 p. 324 - 327
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Citation Number: 12
Abstract
A simple, efficient and environmentally friendly procedure has been developed for the three component coupling of carbonyl compounds, aromatic and aliphatic amines and dialkyl phosphites to produce α-amino phosphonates. The α-amino phosphonates are synthesised in high yields (74-97%) in a few minutes (1-3 min) by microwave irradiation under solvent- free conditions, avoiding the use of any catalyst.
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