Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

K Miyamoto, S Tsuchiya, H Ohta

Index: Miyamoto, Kenji; Tsuchiya, Shigeo; Ohta, Hiromichi Journal of Fluorine Chemistry, 1992 , vol. 59, # 2 p. 225 - 232

Full Text: HTML

Citation Number: 25

Abstract

Abstract α-Methyl-α-(trifluoromethylphenyl) malonic acids have been incubated with Alcaligenesbronchisepticus to afford optically active α-arylpropionic acids. Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing. Decarboxylation of α-fluoro-α- phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro-α- ...