Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants
…, T Kumon, R Kourist, H Ohta, D Uemura, S Yoshida…
Index: Wada, Reina; Kumon, Takashi; Kourist, Robert; Ohta, Hiromichi; Uemura, Daisuke; Yoshida, Shosuke; Miyamoto, Kenji Tetrahedron Letters, 2013 , vol. 54, # 15 p. 1921 - 1923
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Citation Number: 5
Abstract
We have developed a thermally driven domino reaction for the synthesis of (S)-α- arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.
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