Catalytic asymmetric total synthesis of (S)-(−)-zearalenone, a novel lipoxygenase inhibitor
MP Baggelaar, Y Huang, BL Feringa, FJ Dekker…
Index: Baggelaar, Marc P.; Huang, Yange; Feringa, Ben L.; Dekker, Frank J.; Minnaard, Adriaan J. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5271 - 5274
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Citation Number: 6
Abstract
Resorcylic acid lactones are mycotoxins produced by various strains of fungi via polyketide biosynthesis. These medium-sized macrocyclic lactones exhibit a wide variety of interesting biological activities, 1 among which selective kinase inhibition has been characterized very well. 2 Zearalenone, probably the best known member of the resorcylic acid lactones, was first isolated from Gibberella zeae in 1962 3 and four years later its structure was elucidated. 4 ...
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