Tetrahedron

The reaction of 2-fluoroalkyl-1-iodoethylenes with arylamines: a facile method for the synthesis of fluoroalkylated quinolines and enaminoketones

F Zhao, X Yang, J Liu

Index: Zhao, Fulu; Yang, Xianjin; Liu, Jintao Tetrahedron, 2004 , vol. 60, # 44 p. 9945 - 9951

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Citation Number: 7

Abstract

The reaction of 2-fluoroalkyl-1-iodoethylenes with arylamines () and the subsequent acid promoted transformation of the products were described. In the presence of ZnCl2 and triethylamine, reacted readily with various p-substituted anilines in HMPA under a vacuum of 60–70mmHg to give the corresponding enaminoaldehydes () as a mixture of E-and Z- isomers. Cyclization of, without further purification in refluxing toluene, catalyzed by strong ...