Indium-mediated reformatsky-type reaction of β-aminovinyl chlorodifluoromethyl ketones with heteroaryl aldehydes

M Medebielle, O Onomura, R Keirouz, E Okada…

Index: Medebielle, Maurice; Onomura, Osamu; Keirouz, Robert; Okada, Etsuji; Yano, Hirokazu; Terauchi, Terukazu Synthesis, 2002 , # 17 p. 2601 - 2608

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Citation Number: 11

Abstract

In a project devoted to the synthesis of new therapeutic agents, we needed a mild and quick approach for the synthesis of functionalized difluoromethylene β-aminovinyl ketones, as useful starting materials for further chemical elaboration. Mostly trifluoromethylated β-aminovinyl ketones are known, and are frequently used as building blocks for heterocyclic synthesis; [6] [7] however, as far as we know, the reactivity of the C-Cl bond of the ...