Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal …

…, PK Arora, SC Feke, FL Urbach

Index: Sayre; Arora; Feke; Urbach Journal of the American Chemical Society, 1986 , vol. 108, # 9 p. 2464 - 2466

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Citation Number: 28

Abstract

The discovery that 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP, l), present as an impurity in an illicit narcotic preparation, produced an irreversible Parkinson's Disease (PD) syndrome in man1 has led to vigorous research aimed at elucidating the molecular mechanisms responsible for this effect.*" As in PD, MPTP neurotoxicity is associated with the selective destruction of the substantia nigra, a pigmented (neuromelanin) dopaminergic ...