Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) analogs

DS Fries, J De Vries, B Hazelhoff…

Index: Fries; De Vries; Hazelhoff; Horn Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 424 - 427

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Citation Number: 34

Abstract

Six compcunds having structural features in common with l-methyl-4-phenyl-l, 2, 3, 6- tetrahydropyridine(MPTP) were synthesized and tested in mice for the ability to produce a prolonged decrease in nigrostriatal dopamine (DA) and DA metabolites. The compounds that were prepared and tested include the ester elimination products of the analgetic drugs a- prodine and trimeperidine. None of the compounds in this study, except for MPTP, ...