Dopamine receptor model and its application in the design of a new class of rigid pyrrolo [2, 3-g] isoquinoline antipsychotics

…, KD Morgan, JF Blount, L Todaro…

Index: Olson, Gary L.; Cheung, Ho-Chuen; Morgan, Keith D.; Blount, John F.; Todaro, Louis; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 9 p. 1026 - 1034

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Citation Number: 94

Abstract

A hypothetical model of the interaction of antipsychotic drugs with the dopamine receptor is described. This three-dimensional molecular model has been developed on the basis of plausible intermolecular interactions between pharmacophoric groups of diverse types of antipsychotic drugs and postulated amino acid side chain substituents of the receptor protein. Three essential binding sites (one pcsibly required for antagonism) and one ...