Syntheses of an antipsychotic pyrrolo [2, 3-g] isoquinoline from areca alkaloids

…, U Hengartner, DA Katonak, ME Mulligan…

Index: Coffen, David L.; Hengartner, Urs; Katonak, David A.; Mulligan, Mary E.; Burdick, David C.; et al. Journal of Organic Chemistry, 1984 , vol. 49, # 26 p. 5109 - 5113

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Citation Number: 16

Abstract

The synthesis from arecaidine, another one of the areca alkaloids, is the most direct but frequently gives arecolone contaminated with the corresponding tertiary alcohol. Initially, our requirements were met by developing the low-yield route from acrolein reported many years ago by Wohl and Prill. 5 Subsequently, a more reliable and efficient process based on 3- acetylpyridine was worked out. Irrespective of how the arecolone was prepared, it was ...