DIRECT SUBSTITUTION ON THE NITROGEN OF 5, 5-DIALKYLBARBITURIC ACIDS
AW Dox, EG Jones
Index: Dox; Jones Journal of the American Chemical Society, 1929 , vol. 51, p. 317
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Citation Number: 9
Abstract
On account of the high dissociation constant of barbituric acid as compared with that of the 5, 5-dialkylbarbituric acids, Wood and Anderson'concluded that the unsubstituted barbituric acid exists in solution in the tautomeric enol form representing a migration of hydrogen from the methylene to an adjacent carbonyl. As a further proof of this structure they synthesized the sodium salt of barbituric acid from ureidomalonamide and sodium hydroxide, the ...
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