Intelligent fluorescent nucleoside in sensing cytosine base: Importance of hydrophobic nature of perylene fluorophore

…, Y Saito, K Hanawa, S Kodate, I Suzuka, I Saito

Index: Bag, Subhendu Sekhar; Saito, Yoshio; Hanawa, Kazuo; Kodate, Satoshi; Suzuka, Isamu; Saito, Isao Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6338 - 6341

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Citation Number: 24

Abstract

Fluorescence response upon hybridization of perylene labeled oligonucleotide probes depends on the microenvironment experienced by the perylene fluorophore. In mismatched duplex (PerU-C), enhanced fluorescence was observed while in matched duplex (PerU-A) fluorescence intensity decreased considerably. This observation will be a promising research effort in giving rise to a new powerful tool in detection of SNP.