Tetrahedron letters

Synthesis, resolution and applications of 3, 3′-bis (RO)-MeO-BIPHEP derivatives

E Gorobets, GR Sun, BMM Wheatley, M Parvez…

Index: Gorobets, Evgueni; Sun, Guang-Ri; Wheatley, Bronwen M.M.; Parvez, Masood; Keay, Brian A. Tetrahedron Letters, 2004 , vol. 45, # 18 p. 3597 - 3601

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Citation Number: 38

Abstract

A series of optically pure 3, 3′-bis (RO)-MeO-BIPHEP derivatives are prepared and used in palladium catalyzed asymmetric transformations. The phosphine oxide of is prepared in four steps from p-methoxyphenol and resolved using the novel resolving reagent chloro (l- menthoxy) dimethylsilane. Subsequent conversions provide catalysts and. Ligands, and are prepared in six steps from p-methoxyphenol and the phosphine oxides of and, and are ...