Synthesis and evaluation of benzo [b] thiophene derivatives as inhibitors of alkaline phosphatases

…, L Chang, S Pellet-Rostaing, F Liger, M Lemaire…

Index: Li, Lina; Chang, Lei; Pellet-Rostaing, Stephane; Liger, Francois; Lemaire, Marc; Buchet, Rene; Wu, Yuqing Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7290 - 7300

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Citation Number: 32

Abstract

Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alkaline phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for curing rheumatoid arthritis but its therapeutical use is limited due to side effects. We report the synthesis and the TNAP inhibition property of benzo [b] thiophene derivatives, ...