Direct Carboxylation of Thiophenes and Benzothiophenes with the Aid of EtAlCl 2

K Nemoto, S Onozawa, M Konno, N Morohashi…

Index: Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371

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Citation Number: 5

Abstract

Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 6-6-11 Aramaki-Aoba, Aoba-ku, Sendai, Miyagi 980-8579 ... Received November 1, 2011 E-mail: hattori@orgsynth.che.tohoku.ac.jp ... Thiophenes and benzothiophenes bearing alkyl or aryl substituents at the 2- or 3-positions are successfully carboxylated with CO2 with aid of EtAlCl2 to give the corresponding 2- or 3-carboxylic acids in up to 90% yield.