New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase
M Fonvielle, H Therisod, M Hemery…
Index: Fonvielle, Matthieu; Therisod, Helene; Hemery, Marion; Therisod, Michel Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 410 - 413
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Citation Number: 7
Abstract
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6μM, might be of interest as an anti- obesity drug.
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[Merrett, John H.; Spurden, William C.; Thomas, W Anthony; Tong, Brian P.; Whitcombe, Ian W. A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 61 - 68]
[Merrett, John H.; Spurden, William C.; Thomas, W Anthony; Tong, Brian P.; Whitcombe, Ian W. A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 61 - 68]