Highly Efficient and Functional??Group??Tolerant Catalysts for the Palladium??Catalyzed Coupling of Aryl Chlorides with Thiols

MA Fernández??Rodríguez, Q Shen…

Index: Fernandez-Rodriguez, Manuel A.; Shen, Qilong; Hartwig, John F. Chemistry - A European Journal, 2006 , vol. 12, # 30 p. 7782 - 7796

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Citation Number: 184

Abstract

Abstract The cross-coupling reaction of aryl chlorides with aliphatic and aromatic thiols catalyzed by palladium complexes of the strongly binding bisphosphine CyPF-tBu ligand (1) is reported. Most of the reactions catalyzed by complexes of ligand 1 occur with turnover numbers that exceed those of previous catalysts by two orders of magnitude. The reactions occur with excellent yields, broad scope and high tolerance of functional groups. Coupling ...

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