Combinatorial synthesis and high-throughput screening of alkyl amines for nonviral gene delivery
…, F Wang, Y Wu, G Davidson, PA Levkin
Index: Li, Linxian; Wang, Fengjian; Wu, Yihang; Davidson, Gary; Levkin, Pavel A. Bioconjugate Chemistry, 2013 , vol. 24, # 9 p. 1543 - 1551
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Citation Number: 11
Abstract
Efficient delivery of plasmid DNA and siRNA into cells is essential for biological and biomedical research. Although significant efforts have been made to develop efficient nonviral vectors, such as cationic lipids and polymers, most of the vectors require multistep synthesis, which complicates both fast structural optimizations and combinatorial synthesis of such vectors. Here, we present a facile, single-step method based on an alkylation of ...
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