Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives

AF Taveira, M Le Hyaric, EFC Reis, DP Araújo…

Index: Taveira, Aline F.; Hyaric, Mireille Le; Reis, Elaine F.C.; Araujo, Debora P.; Ferreira, Ana Paula; de Souza, Maria Aparecida; Alves, Livia L.; Lourenco, Maria C.S.; Vicente, Felipe Rodrigues C.; de Almeida, Mauro V. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7789 - 7794

Full Text: HTML

Citation Number: 19

Abstract

A series of N-and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5 μg/mL. The presence of the carbohydrate slightly affected the antibacterial activity.