Synthesis, staining properties, and biocompatibility of a new cyanine dye for ILM peeling

C Haritoglou, M Kernt, P Laubichler, H Langhals…

Index: Langhals, Heinz; Varja, Ana; Laubichler, Peter; Kernt, Marcus; Eibl, Kirsten; Haritoglou, Christos Journal of Medicinal Chemistry, 2011 , vol. 54, # 11 p. 3903 - 3925

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Citation Number: 5

Abstract

Abstract Background The aim of this work is to investigate the biocompatibility and staining properties of DSS: 3, 3′-Di-(4-sulfobutyl)-1, 1, 1′, 1′-tetramethyl-di-1 H-benz [e] indocarbocyanine (DSS). Methods Dye concentrations of 0.5, 0.25, and 0.1% were evaluated (290 and 295 mOsm). Toxicity was assessed using a colorimetric test measuring the inhibition of ARPE 19 cell, human primary RPE cell, and human Müller cell ...