Rhodium (I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines
KM Brummond, H Chen, B Mitasev, AD Casarez
Index: Brummond, Kay M.; Chen, Hongfeng; Mitasev, Branko; Casarez, Anthony D. Organic Letters, 2004 , vol. 6, # 13 p. 2161 - 2163
Full Text: HTML
Citation Number: 53
Abstract
A novel strategy for the preparation of seven-membered heterocyclic compounds has been realized. Treatment of ene-allene 1 with a catalytic quantity of rhodium biscarbonyl chloride dimer affords the cyclization product 2 in moderate to high yields. The scope and limitations of this new method are currently under investigation, and the results obtained to date are discussed within.
Related Articles:
Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions
[Gracias, Vijaya; Gasiecki, Alan F.; Djuric, Stevan W. Tetrahedron Letters, 2005 , vol. 46, # 52 p. 9049 - 9052]
[Li, Yanwu; Marks, Tobin J. Journal of the American Chemical Society, 1998 , vol. 120, # 8 p. 1757 - 1771]
Synthesis of New Vinyl Thiocyanates by [3, 3] Sigmatropic Rearrangement of Isothiocyanates
[Banert, Klaus; Hagedorn, Manfred; Mueller, Anett European Journal of Organic Chemistry, 2001 , # 6 p. 1089 - 1103]