3-[2-[4-(4-Fluorobenzoyl) piperidin-1-yl] ethyl]-5, 6, 7, 8-tetrahydro-4 (3H)-quinazolinones: serotonin 5-HT 2A receptor antagonists endowed with potent central action

F Claudi, G Giorgioni, L Scoccia, R Ciccocioppo…

Index: Claudi; Giorgioni; Scoccia; Ciccocioppo; Panocka; Massi European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 651 - 659

Full Text: HTML

Citation Number: 9

Abstract

A series of 5, 6, 7, 8-tetrahydro-4 (3H)-quinazolinones substituted at the 3-position with 4- benzoyl-1-ethylpiperidine, 4-(4-fluorobenzoyl)-1-ethylpiperidine, 4-[bis-(4-fluorophenyl) methylene]-1-ethylpiperidine, or 4-(4-fluorophenyl)-1-propylpiperazine have been prepared and evaluated in binding assays to determine their affinity at serotonin 5-HT2A receptors as well as in a functional test, ie, wet dog shakes (WDS) induced by L-5-hydroxytryptophan (L ...