Utility of azetidinium methanesulfonates for radiosynthesis of 3??[18F] fluoropropyl amines

DO Kiesewetter, WC Eckelman

Index: Kiesewetter, Dale O.; Eckelman, William C. Journal of Labelled Compounds and Radiopharmaceuticals, 2004 , vol. 47, # 13 p. 953 - 969

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Citation Number: 8

Abstract

Abstract 3-Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat-induced cyclization of 3- methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [18 F] fluoride (decay-corrected yields> 60%) efficiently, resulting in an efficient ...