Preparation of Primary Amines by the Alkylation of O-Sulfonyloximes of Benzophenone Derivatives with Grignard Reagents.
H Tsutsui, T Ichikawa, K Narasaka
Index: Tsutsui, Hironori; Ichikawa, Tomoko; Narasaka, Koichi Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 8 p. 1869 - 1878
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Citation Number: 47
Abstract
Primary amines are prepared by the electrophilic amination of Grignard reagents with benzophenone O-sulfonyloxime derivatives. 4, 4′-Bis (trifluoromethyl) benzophenone O- sulfonyloximes react with alkyl Grignard reagents in the presence of a catalytic amount of CuCN in tetrahydrofuran-hexamethylphosphoric triamide to give N-alkylimines, which are readily hydrolyzed to primary amines. 3, 3′, 5, 5′-Tetrakis (trifluoromethyl) ...
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