trans-4-[4-(Methoxyphenyl) cyclohexyl]-1-arylpiperazines: A New Class of Potent and Selective 5-HT1A Receptor Ligands as Conformationally Constrained …
…, M Leopoldo, E Lacivita, V Tortorella…
Index: Perrone; Berardi; Colabufo; Leopoldo; Lacivita; Tortorella; Leonardi, Amedeo; Poggesi, Elena; Testa, Rodolfo Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4431 - 4442
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Citation Number: 29
Abstract
The present paper concerns the influence of conformational parameters on the recognition by rat 5-HT1A receptors of derivatives 4-[3-(5-methoxy-1, 2, 3, 4-tetrahydronaphthalen-1-yl) propyl]-1-(2-pyridinyl) piperazine (1a) and 3-(5-methoxy-1, 2, 3, 4-tetrahydronaphthalen-1- yl)-N-[2-(2-pyridyloxy) ethyl] propanamine (3b), two highly potent and selective 5-HT1A receptor ligands. Fifteen corresponding flexible and rigid analogues were prepared ...
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