Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N′-(methoxyphenylalkyl) piperazine σ 1 receptor ligands

IA Moussa, SD Banister, FN Akladios, SW Chua…

Index: Moussa, Iman A.; Banister, Samuel D.; Akladios, Fady N.; Chua, Sook Wern; Kassiou, Michael Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5707 - 5710

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Citation Number: 9

Abstract

In our continued exploration of disubstituted piperazine derivatives as sigma (σ) receptor ligands with central nervous system (CNS) activity, a series of N-(2-benzofuranylmethyl)-N′- (methoxyphenylalkyl) piperazines (16–21 and 26–31) were synthesized, anticipating that these ligands would better suit the structural requirements of the current σ1 pharmacophore. Affinities of these ligands for σ1 and σ2 receptors were investigated by means of ...