Traceless solid-phase synthesis of mappicine ketone library via multiple chemoselective palladium-catalyzed reactions on benzenesulfonate linker
H Tsukamoto, R Suzuki, Y Kondo
Index: Tsukamoto, Hirokazu; Suzuki, Risako; Kondo, Yoshinori Synlett, 2008 , # 13 p. 2005 - 2010
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Citation Number: 2
Abstract
Abstract We report here a solid-phase synthesis of a library of mappicine ketone, a leading antiviral compound with activity against herpes viruses and human cytomegalovirus. The synthesis is based on multiple chemoselective palladium-catalyzed reactions involving a regioselective intramolecular Heck reaction at C-2, substitution of Cl at C-7 by Suzuki- Miyaura cross-coupling reaction and Buchwald-Hartwig amination, and reductive ...
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