Tetrahedron

A synthetic approach to 2, 3, 4-substituted pyridines useful as scaffolds for tripeptidomimetics

S Saitton, J Kihlberg, K Luthman

Index: Saitton, Stina; Kihlberg, Jan; Luthman, Kristina Tetrahedron, 2004 , vol. 60, # 29 p. 6113 - 6120

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Citation Number: 32

Abstract

The synthesis of 2, 3, 4-substituted pyridine derivatives useful as scaffolds in the development of peptidomimetics is described. The use of a variety of electrophiles in a halogen-dance reaction to produce 3-alkyl-2-fluoro-4-iodo-pyridine derivatives as 'functionalized scaffolds' and the possibility to differentiate between the reactivities of the two halogen handles have been explored. Coupling of amino acid derivatives in the 4-position ...