Simple and Sustainable Iron-Catalyzed Aerobic C–H Functionalization of N, N-Dialkylanilines
MO Ratnikov, X Xu, MP Doyle
Index: Ratnikov, Maxim O.; Xu, Xinfang; Doyle, Michael P. Journal of the American Chemical Society, 2013 , vol. 135, # 25 p. 9475 - 9479
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Citation Number: 71
Abstract
Iron (III) chloride catalyzes the aerobic oxidation of tertiary anilines, including tetrahydroisoquinolines, to form reactive iminium ion intermediates that undergo Mannich reactions with silyloxyfurans, nitroalkanes, and other nucleophiles to give the corresponding butenolides, nitro compounds, and α-substituted tetrahydroisoquinolines, respectively, in good to excellent yields.
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