Thiosemicarbazide, a fragment with promising indolamine-2, 3-dioxygenase (IDO) inhibition properties

…, L Moineaux, C Vancraeynest, B Masereel…

Index: Serra, Silvia; Moineaux, Laurence; Vancraeynest, Christelle; Masereel, Bernard; Wouters, Johan; Pochet, Lionel; Frederick, Raphael European Journal of Medicinal Chemistry, 2014 , vol. 82, p. 96 - 105

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Citation Number: 4

Abstract

Abstract With the aim to explore the interest of the thiosemicarbazide scaffold for the inhibition of the indoleamine 2, 3-dioxygenase (IDO), a promising therapeutic target for anticancer immunotherapy, a series of 32 phenylthiosemicarbazide derivatives was prepared and their IDO inhibition evaluated. Our study demonstrated that among these derivatives, compound 14 characterized with a 4-cyanophenyl group on the ...