Distamycin Analogues without Leading Amide at Their N??Termini− Comparative Binding Properties to AT??and GC??Rich DNA Sequences

…, U Varshney, S Bhattacharya

Index: Thomas, Mini; Varshney, Umesh; Bhattacharya, Santanu European Journal of Organic Chemistry, 2002 , # 21 p. 3604 - 3615

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Citation Number: 28

Abstract

Abstract An efficient, simple and general route towards the solution-phase synthesis of four distamycin analogues containing 2− 5 N-methylcarboxamide units without the leading amide unit at the N-terminus is described. The binding abilities of these molecules to calf thymus DNA, poly d (AT), poly dA. poly dT and poly d (GC) were evaluated by duplex DNA melting temperature (T m) analysis, fluorescence probe displacement assay, footprinting ...