Synthesis and cytotoxicity evaluation of novel C7–C7, C7–N3 and N3–N3 dimers of 1-chloromethyl-5-hydroxy-1, 2-dihydro-3 H-benzo [e] indole (seco-CBI) with …

R Kumar, JW Lown

Index: Kumar, Rohtash; Lown, J William Organic and biomolecular chemistry, 2003 , vol. 1, # 15 p. 2630 - 2647

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Citation Number: 14

Abstract

DNA has for many years been a traditional target for chemotherapeutic intervention 1 in human cancers, especially for those where high proliferation rates of some tumor cell types have resulted in sensitivity to drugs, which block replication and transcription of their DNA. 2 Substantial progress has been made in understanding the fundamental principles responsible for the sequence-selective recognition of DNA by small organic molecules 3 including a range of naturally occurring ...