Convenient copper-and solvent-free Sonogashira-type alkynylation of aryl iodides and bromides using Pd EnCat™
A Carpita, A Ribecai
Index: Carpita, Adriano; Ribecai, Arianna Tetrahedron Letters, 2009 , vol. 50, # 2 p. 204 - 207
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Citation Number: 42
Abstract
A straightforward methodology is described for the copper-and solvent-free alkynylations of aryl iodides and bromides using 0.1–0.01 mol% of Pd as Pd EnCat™ 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides; a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions.
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