Tetrahedron letters

Synthesis of chiral zileuton, a potent and selective inhibitor of 5-lipoxygenase

CN Hsiao, T Kolasa

Index: Hsiao, Chi-Nung; Kolasa, Teodozyj Tetrahedron Letters, 1992 , vol. 33, # 19 p. 2629 - 2632

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Citation Number: 44

Abstract

Abstract Coupling and intramolecular Wittig reaction of N-benzyloxy-D-alanine anhydride (13) and (2-Mercaptophenyl) methyltriphenylphosphonium bromide (3) were used as key steps to prepare (+)-enantiomer of zileuton (1), a potent and selective inhibitor of 5- lipoxygenase.