Zinc??Catalyzed Enantiospecific sp3–sp3 Cross??Coupling of α??Hydroxy Ester Triflates with Grignard Reagents

C Studte, B Breit

Index: Studte, Christopher; Breit, Bernhard Angewandte Chemie - International Edition, 2008 , vol. 47, # 29 p. 5451 - 5455

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Citation Number: 56

Abstract

Skeleton-expanding operations that provide control of all levels of selectivity are among the most valuable transformations in organic synthesis.[1] One important example is the alkylation of ester or amide enolates which requires either a chiral auxiliary or stoichiometric amounts of a chiral base in order to control the absolute configuration of the final alkylation product.[2–5]