Synthesis of trans-vaccenic acid and cis-9-trans-11-conjugated linoleic acid

PE Duffy, SM Quinn, HM Roche, P Evans

Index: Duffy, Patricia E.; Quinn, Sonia M.; Roche, Helen M.; Evans, Paul Tetrahedron, 2006 , vol. 62, # 20 p. 4838 - 4843

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Citation Number: 12

Abstract

The preparation of the monounsaturated fatty acid, trans-vaccenic acid (TVA), using both Wittig and one-pot Julia-Kocieński olefination protocol, was achieved in good yield. Similarly a Wittig approach was employed for the stereoselective synthesis of cis-9-trans-11- conjugated linoleic acid from trans-2-nonenal and (8-carboxyoctyl) triphenylphosphonium bromide.