Tetrahedron letters

An asymmetric dihydroxylation route to enantiomerically pure norfluoxetine and fluoxetine

RK Pandey, RA Fernandes, P Kumar

Index: Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426

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Citation Number: 55

Abstract

An efficient, practical asymmetric synthesis of (R)-norfluoxetine 1 and (R)-fluoxetine 2 has been achieved. The synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the common building block 1, 3-amino alcohol 9, from which (R)- norfluoxetine,(R)-fluoxetine and other related analogs can be synthesized.

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