Tetrahedron: Asymmetry

One-pot synthesis of enantiomerically pure 1, 2-diols: asymmetric reduction of aromatic α-oxoaldehydes catalysed by Candida parapsilosis ATCC 7330

P Mahajabeen, A Chadha

Index: Mahajabeen, Pula; Chadha, Anju Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2156 - 2160

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Citation Number: 17

Abstract

A facile and simple one-pot method was developed to produce a series of optically active (S)- 1-phenyl-1, 2-ethanediols with good yields (up to 70%) and high enantiomeric excess (> 99%) via asymmetric reduction of various substituted aromatic α-oxoaldehydes using Candida parapsilosis ATCC 7330.

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