Synthesis and Antifungal Activity of 1??[(2??Benzyloxy) Phenyl]??2??(Azol??1??yl) Ethanone Derivatives: Exploring the Scaffold Flexibility

…, M Falahati, R Fateh, M Ashrafi??Khozani

Index: Emami, Saeed; Kazemi-Najafabadi, Motahare; Pashangzadeh, Soughra; Foroumadi, Alireza; Faramarzi, Mohammad Ali; Samadi, Nasrin; Falahati, Mehraban; Fateh, Roohollah; Ashrafi-Khozani, Mahtab Chemical Biology and Drug Design, 2011 , vol. 78, # 6 p. 979 - 987

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Citation Number: 4

Abstract

Based on the N-(phenethyl) azole backbone of azole antifungals, we designed 1-[(2- benzyloxy) phenyl]-2-(azol-1-yl) ethanone derivatives 2 and 3, containing benzyloxyphenyl scaffold of croconazole. Also these compounds can be considered as flexible analogs, resulted from C2–C3 disconnection of 3¢-chloro-3-imidazolylflavanone 1, recently described as antifungal agent. Thus, in this report, we describe the synthesis of 1-[(2-benzyloxy) ...