Synthesis, in vitro antifungal activity and in silico study of 3-(1, 2, 4-triazol-1-yl) flavanones

…, S Shojapour, MA Faramarzi, N Samadi…

Index: Emami, Saeed; Shojapour, Shahaboddin; Faramarzi, Mohammad Ali; Samadi, Nasrin; Irannejad, Hamid European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 480 - 488

Full Text: HTML

Citation Number: 8

Abstract

Abstract A series of novel 3-(1, 2, 4-triazol-1-yl) flavanones were synthesized based on the N- phenethylazole pharmacophore of azole antifungals. The results of antifungal assay revealed that 4′-fluoroflavanone derivative 4c exhibited the best profile of activity against Candida and Saccharomyces strains. Compound 4c was 4–16 times more potent than reference drug fluconazole against Candida albicans and Saccharomyces cerevisiae. The ...