Tetrahydroquinolines by Lewis Acid-promoted Friedel-Crafts Cyclizations
RA Bunce, NR Cain, JG Cooper
Index: Bunce, Richard A.; Cain, Nicholas R.; Cooper, John G. Organic Preparations and Procedures International, 2013 , vol. 45, # 1 p. 28 - 43
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Citation Number: 3
Abstract
Two recent projects described approaches to 1, 1-dimethyl-1, 2, 3, 4- tetrahydronaphthalenes1 and 4, 4-dimethyl-1, 2, 3, 4-tetrahydroisoquinolines2 using acid- promoted Friedel-Crafts cyclizations. Both of these ring systems are of interest to us for the synthesis of structures with potential biological activity. The current work explores a further use of this strategy for the synthesis of tetrahydroquinolines bearing gem-dimethyl ...
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