New amino-protective reagents for t-butoxycarbonylation and benzyloxycarbonylation of amines and amino acids.
S Kim, JI Lee, KY Yi
Index: Kim, Sunggak; Lee, Jae In; Yi, Kyu Yang Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 12 p. 3570 - 3575
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Citation Number: 22
Abstract
New amino-protective reagents for t-butoxycarbonylation and benzyloxycarbonylation of amines and amino acids have been developed. t-Butyl 2-pyridyl carbonate and t-butyl S-(2- pyridyl) thiocarbonate react cleanly with various amines and amino acids to afford N-Boc amines and N-Boc amino acids in high yields. Benzyl 2-pyridyl carbonate and O-benzyl S-(2- pyridyl) thiocarbonate are also found to be very effective in the benzyloxycarbonylation of ...
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