Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia
SY Lee, E Moon, SY Kim, KR Lee
Index: Lee, Seung Young; Moon, Eunjung; Kim, Sun Yeou; Lee, Kang Ro Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2140 - 2144
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Citation Number: 15
Abstract
Five new quinic acid derivatives (1–5), together with 10 known quinic acid derivatives (6– 15), were isolated from the MeOH extract of Pimpinella brachycarpa (Umbelliferae). Their structures were established on the basis of spectroscopic analyses including extensive 2D NMR studies (COSY, HMQC and HMBC). Isolated compounds 1–15 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell ...
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